TY - JOUR T1 - Impact of Stereotactic Radiosurgery Dose on Control of Cerebral Metastases from Renal Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 3571 LP - 3574 VL - 35 IS - 6 AU - DIRK RADES AU - STEFAN HUTTENLOCHER AU - NIKLAS GEBAUER AU - DAGMAR HORNUNG AU - NGO THUY TRANG AU - MAI TRONG KHOA AU - STEVEN E. SCHILD Y1 - 2015/06/01 UR - http://ar.iiarjournals.org/content/35/6/3571.abstract N2 - Aim: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Patients and Methods: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy. Results: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006). Conclusion: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy. ER -