RT Journal Article
SR Electronic
T1 A Cohort Study Evaluating the Role of Surgery for Lung Metastases from Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3431
OP 3435
VO 35
IS 6
A1 FRANCISCO SOCOLA
A1 DAO M. NGUYEN
A1 ROBERTO E. OCHOA
A1 CAIO M. ROCHA LIMA
A1 PETER J. HOSEIN
YR 2015
UL http://ar.iiarjournals.org/content/35/6/3431.abstract
AB Background/Aim: Surgery may be curative in some patients with metastatic colorectal cancer (mCRC). We analyzed the role of lung metastatectomy in this population. Patients and Methods: In this retrospective cohort study, cases were defined as mCRC patients with lung metastases (LM's) who underwent metastatectomy. Controls had LM's but did not undergo resection. Results: There were 28 cases and 46 controls. The median overall survival (OS) was 53 months among the cases and 26.3 months for the controls. The cases were more likely to have 1 or 2 lung metastases, unilateral versus bilateral LM's, metachronous versus synchronous presentation of LM's and more likely to have a carcinoembryonic antigen (CEA) level less than 10 ng/ml at diagnosis. The interval from diagnosis to the development of lung metastases was significantly longer in cases versus controls (22.9 versus 8.5 months). Conclusion: Patients selected using these criteria may have prolonged survival with therapy that includes lung metastatectomy.