PT  - JOURNAL ARTICLE
AU  - LIANG-YU CHEN
AU  - CHIA-CHANG HUANG
AU  - YUNG-AN TSOU
AU  - DA-TIAN BAU
AU  - MING-HSUI TSAI
TI  - Prognostic Factor of Severe Complications in Patients with Hypopharyngeal Cancer with Primary Concurrent Chemoradiotherapy
DP  - 2015 Mar 01
TA  - Anticancer Research
PG  - 1735--1741
VI  - 35
IP  - 3
4099  - http://ar.iiarjournals.org/content/35/3/1735.short
4100  - http://ar.iiarjournals.org/content/35/3/1735.full
SO  - Anticancer Res2015 Mar 01; 35
AB  - Background/Aim: Organ-preservation treatment for hypopharyngeal cancer has recently become a popular treatment option. However, the severe complications and poor quality of life after non-surgical treatment should be avoided. We accessed the laryngeal or pharyngeal dysfunction-related complications after concurrent chemoradiotherapy (CCRT) as the primary treatment for hypopharyngeal cancer. Patients and Methods: Data concerning all patients treated for hypopharyngeal cancer with primary non-surgical treatment at the China Medical University Hospital from 2002 to 2012 were retrospectively reviewed. Results: A total of 161 patients were included with a median age of 56.6 years. The disease control rates (disease-free >12 months) and severe complication rates were correlated to the tumor (T) stage and nodal (N) stage. In the successful treatment group, the complication rate was related to the N stage. The overall pharyngeal dysfunction, laryngeal dysfunction and aspiration rates were 36%, 27% and 25%, respectively. For patients with T4a disease, hyoid bone invasion significantly increased the severe complication rate (p=0.0212). Conclusion: The treatment outcome was correlated to the T and N stage. A higher rate of laryngopharyngeal dysfunction occurred when treating hyoid bone invasion in T4a patients with primary non-surgical treatment. In advanced stage, but still resectable hypopharyngeal tumors, the poorer quality of life due to non-function larynx was noted after treating with CCRT.