RT Journal Article
SR Electronic
T1 Radiation-induced Second Malignancies
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2431
OP 2434
VO 35
IS 4
A1 SHAZIA MAHMOOD
A1 KHANH VU
A1 PATRICIA TAI
A1 KURIAN JOSEPH
A1 RASHMI KOUL
A1 ARBIND DUBEY
A1 EDWARD YU
YR 2015
UL http://ar.iiarjournals.org/content/35/4/2431.abstract
AB Background: The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to shared etiologic exposures. Patients and Methods: This article focuses on radiation-induced malignancies with illustrative cases of thyroid, rectal cancer and sarcoma. Results: The detection and management of radiation-induced malignancies of some case scenarios are presented. Second malignancies are detected within previous radiation field and the time intervals from previous tumor vary from 8 to 21 years. Conclusion: Clinicians should aim to reduce radiation-induced malignancies by careful selection of patients and radiation techniques before radiotherapy. Subsequent vigilant follow-up and investigations can detect these radiation-induced malignancies early and, hence, result in successful treatment.