TY - JOUR T1 - Bevacizumab and Postoperative Wound Complications in Patients with Liver Metastases of Colorectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 2255 LP - 2261 VL - 35 IS - 4 AU - HIROFUMI UTSUMI AU - YOSHITAKA HONMA AU - KENGO NAGASHIMA AU - SATORU IWASA AU - ATSUO TAKASHIMA AU - KEN KATO AU - TETSUYA HAMAGUCHI AU - YASUHIDE YAMADA AU - YASUHIRO SHIMADA AU - YOJI KISHI AU - SATOSHI NARA AU - MINORU ESAKI AU - KAZUAKI SHIMADA Y1 - 2015/04/01 UR - http://ar.iiarjournals.org/content/35/4/2255.abstract N2 - Aim: The present study investigated whether bevacizumab (BV) is associated with postoperative wound complications (PWCs). Patients and Methods: We retrospectively analyzed patients undergoing surgery for liver metastases of colorectal cancer at our Institution. Patients were divided into 3 groups according to the preoperative treatment: che mo therapy with BV (group A), chemotherapy without BV (group B) and no chemotherapy (group C). Results: Between February 2003 and September 2012, 297 patients underwent 373 surgeries. Groups A, B and C consisted of 23, 62 and 288 patients, respectively. PWCs occurred in 29 patients (7.8%). In multivariate analysis, there were no differences in PWCs among the groups (C vs. B:P=0.739; C vs. A: P=0.110). Conversely, lower serum albumin levels (<3.5g/dl vs. ≥3.5g/dl: p=0.030) and synchronous colorectal resection (no vs. yes; p<0.001) remained significant risk factors of developing PWCs. Conclusion: Chemotherapy with or without BV did not influence the risk of PWCs. ER -