TY - JOUR T1 - Effects of Antioxidants and Pro-oxidants on Cytotoxicity of Dihydroartemisinin to Molt-4 Human Leukemia Cells JF - Anticancer Research JO - Anticancer Res SP - 1867 LP - 1871 VL - 35 IS - 4 AU - THOMAS GERHARDT AU - ROSS JONES AU - JUNGSOO PARK AU - RUI LU AU - HO WING CHAN AU - QINGXI FANG AU - NARENDRA SINGH AU - HENRY LAI Y1 - 2015/04/01 UR - http://ar.iiarjournals.org/content/35/4/1867.abstract N2 - Background: The objective of the present study was to investigate how oxidative status influences the effective ness of cytotoxicity of artemisinin towards cancer cells. It is hypothesized that antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity. Materials and Methods: Molt-4 human leukemia cells were incubated with vitamins C, E, D3, dexamethasone, or hydrogen peroxide alone or in combination with dihydroartemisinin (DHA). Concentrations of these compounds studied were similar to those achievable by oral administration. Viable cell counts were performed before (0 h) and at, 24 and 48 h after treatment. Results: Vitamin C, vitamin D3, dexamethasone, and H2O2 caused significant Molt-4 cell death. Vitamin E caused an increase in Molt-4 cell growth. Vitamin C and vitamin D3 significantly interacted with DHA at the 48-h time point and with H2O2 at both 24-h and 48-h time points. Conclusion: Cellular oxidative status could alter the potency of artemisinin in killing cancer cells. ER -