RT Journal Article SR Electronic T1 Antiviral Therapy and Long-term Outcome for Hepatitis B Virus-related Hepatocellular Carcinoma after Curative Liver Resection in a Japanese Cohort JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1647 OP 1655 VO 35 IS 3 A1 KEITA SAKAMOTO A1 TORU BEPPU A1 HIROMITSU HAYASHI A1 SHIGEKI NAKAGAWA A1 HIROHISA OKABE A1 HIDETOSHI NITTA A1 KATSUNORI IMAI A1 DAISUKE HASHIMOTO A1 AKIRA CHIKAMOTO A1 TAKATOSHI ISIKO A1 KEN KIKUCHI A1 HIDEO BABA YR 2015 UL http://ar.iiarjournals.org/content/35/3/1647.abstract AB Aim: The aim of this study was to determine whether antiviral therapy with nucleotide/nucleoside analog (NA) is beneficial for Japanese patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) who underwent initial curative liver resection. Patients and Methods: In 162 patients with positive hepatitis B surface antigen and negative anti-hepatitis C virus antibody, sixty-two patients received antiviral therapy with NA (NA group) and the remaining 100 patients did not (non-NA group). Prognostic factors for disease-free survival (DFS) and overall survival (OS) were evaluated. Moreover, to equalize the background covariates, a one-to-one propensity case-matched analysis was used. Results: NA administered were lamivudine (LAM) solely for 21 patients, LAM plus adefovir dipivoxil (ADV) for 6, LAM switched to entecavir (ETV) for 5 and ETV solely for 31. DFS did not significantly differ between the NA group and non-NA group (p=0.19). However, OS was significantly different (p=0.0063); 1-,3- and 5-year OS were 100% and 85.9%, 88.3% and 61.9% and 65.1% and 58.0%, respectively. In multivariate analysis, no antiviral therapy with NA was an independent poor prognostic factor (hazard ratio (HR)=2.72; p=0.0229). However, after propensity case-matched analysis, disease-free and overall survival were not significantly different between the two groups. Conclusion: In a Japanese cohort, antiviral therapy with NAs might provide longer survival for postoperative HBV-related HCC patients compared to patients without antiviral therapy. However, deterministic evaluation was impossible by this study alone.