RT Journal Article
SR Electronic
T1 A Long Noncoding RNA, lncRNA-ATB, Is Involved in the Progression and Prognosis of Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1385
OP 1388
VO 35
IS 3
A1 IGUCHI, TOMOHIRO
A1 UCHI, RYUTARO
A1 NAMBARA, SHO
A1 SAITO, TOMOKO
A1 KOMATSU, HISATERU
A1 HIRATA, HIDENARI
A1 UEDA, MASAMI
A1 SAKIMURA, SHOTARO
A1 TAKANO, YUKI
A1 KURASHIGE, JYUNJI
A1 SHINDEN, YOSHIAKI
A1 EGUCHI, HIDETOSHI
A1 SUGIMACHI, KEISHI
A1 MAEHARA, YOSHIHIKO
A1 MIMORI, KOSHI
YR 2015
UL http://ar.iiarjournals.org/content/35/3/1385.abstract
AB Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNA-ATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the high-lncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.