PT - JOURNAL ARTICLE AU - IGUCHI, TOMOHIRO AU - UCHI, RYUTARO AU - NAMBARA, SHO AU - SAITO, TOMOKO AU - KOMATSU, HISATERU AU - HIRATA, HIDENARI AU - UEDA, MASAMI AU - SAKIMURA, SHOTARO AU - TAKANO, YUKI AU - KURASHIGE, JYUNJI AU - SHINDEN, YOSHIAKI AU - EGUCHI, HIDETOSHI AU - SUGIMACHI, KEISHI AU - MAEHARA, YOSHIHIKO AU - MIMORI, KOSHI TI - A Long Noncoding RNA, lncRNA-ATB, Is Involved in the Progression and Prognosis of Colorectal Cancer DP - 2015 Mar 01 TA - Anticancer Research PG - 1385--1388 VI - 35 IP - 3 4099 - http://ar.iiarjournals.org/content/35/3/1385.short 4100 - http://ar.iiarjournals.org/content/35/3/1385.full SO - Anticancer Res2015 Mar 01; 35 AB - Background/Aim: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNA-ATB in colorectal cancer (CRC). Materials and Methods: lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression. Results: High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the high-lncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases. Conclusion: lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.