PT  - JOURNAL ARTICLE
AU  - DREES, JEREMY
AU  - MERTENSOTTO, MICHAEL
AU  - LIU, GARVEY
AU  - PANYAM, JAYANTH
AU  - LEONARD, ARNOLD
AU  - AUGUSTIN, LANCE
AU  - SCHOTTEL, JANET
AU  - SALTZMAN, DANIEL
TI  - Attenuated <em>Salmonella enterica</em> Typhimurium Reduces Tumor Burden in an Autochthonous Breast Cancer Model
DP  - 2015 Feb 01
TA  - Anticancer Research
PG  - 843--849
VI  - 35
IP  - 2
4099  - http://ar.iiarjournals.org/content/35/2/843.short
4100  - http://ar.iiarjournals.org/content/35/2/843.full
SO  - Anticancer Res2015 Feb 01; 35
AB  - Background/Aim: Cancer treatment with attenuated Salmonella enterica Typhimurium (S. Typhimurium) has gained momentum in recent years. However, the effectiveness of this treatment has not been explored in autochthonous models. We report the efficacy of S. Typhimurium in mice with autochthonous mammary tumors. Materials and Methods: S. Typhimurium attenuated by deletion of cyclic adenosine monophosphate signaling, SalpNG.1, was injected into female BALB-neuT tumor-bearing mice. Mice were monitored for efficacy and sacrificed for mechanistic studies. Results: In treated mice, seven-week post-treatment tumor burden was reduced by 85% and median survival was increased by 88%. Efficacy was correlated with increased tumor-infiltrating CD8 and natural killer cells. In addition, SalpNG.1 treatment caused a systemic increase of monocytic myeloid-derived suppressor cells that accumulated to high numbers within tumor tissue. Bacteria were not detected in tumor tissue, suggesting that the observed efficacy was due to a systemic rather than a tumor-specific effect of the bacteria. Conclusion: S. Typhimurium treatment reduces tumor burden and increases survival in an autochthonous breast cancer model.