PT  - JOURNAL ARTICLE
AU  - TOMOYUKI OKUMURA
AU  - YUTAKA SHIMADA
AU  - TETSUYA OMURA
AU  - KATSUHISA HIRANO
AU  - TAKUYA NAGATA
AU  - KAZUHIRO TSUKADA
TI  - MicroRNA Profiles to Predict Postoperative Prognosis in Patients with Small Cell Carcinoma of the Esophagus
DP  - 2015 Feb 01
TA  - Anticancer Research
PG  - 719--727
VI  - 35
IP  - 2
4099  - http://ar.iiarjournals.org/content/35/2/719.short
4100  - http://ar.iiarjournals.org/content/35/2/719.full
SO  - Anticancer Res2015 Feb 01; 35
AB  - Background/Aim: Small cell carcinoma of the esophagus (SCCE) is a rare but very aggressive disease with poor prognosis. The aim of the present study was to identify a molecular signature to predict postoperative outcomes in patients with SCCE. Materials and Methods: Expression of microRNA was detected in surgically-removed SCCE tumors using microarrays. A SCCE cell line (TYUC-1) was established to investigate the biological role of differentially expressed microRNAs. Results: Hierarchical clustering of microRNA expression revealed two discrete clusters that were identical to the cases with rapid tumor relapse (n=3; median survival, 5.1 months) and the cases with long-term survival (n=3; median observation, 144.7 months), respectively. Eight microRNAs (miR-4323, miR-625, miR-3619-3p, miR-4419b, miR-1249, miR-4648, miR-4664-3p and miR-1203) showed significant correlation with tumor relapse (p<0.01). Migration of TYUC-1 was significantly inhibited by down-regulation of miR-625. Conclusion: The expression profiles of microRNAs in tumors may represent a novel predictor for postoperative outcomes in patients with SCCE.