TY - JOUR T1 - Differential Contribution of ROS to Resveratrol-induced Cell Death and Loss of Self-renewal Capacity of Ovarian Cancer Stem Cells JF - Anticancer Research JO - Anticancer Res SP - 85 LP - 96 VL - 35 IS - 1 AU - MANABU SEINO AU - MASASHI OKADA AU - KEITA SHIBUYA AU - SHIZUKA SEINO AU - SHUHEI SUZUKI AU - HIROYUKI TAKEDA AU - TSUYOSHI OHTA AU - HIROHISA KURACHI AU - CHIFUMI KITANAKA Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/85.abstract N2 - Background/Aim: Cancer stem cells (CSCs) are considered to contribute to the poor prognosis of ovarian cancer as a major cause of fatal recurrence. Identification of effective measures to eliminate ovarian CSCs through induction of cell death and/or loss of self-renewal capacity would, therefore, be key to successful management of ovarian cancer. Materials and Methods: The effects of resveratrol on the viability and self-renewal capacity of CSCs derived from A2780 human ovarian cancer cells were examined. The involvement of reactive oxygen species (ROS) was also investigated. Results: At a non-toxic to normal human fibroblasts concentration, resveratrol effectively killed ovarian CSCs independently of ROS, while ROS-dependently impaired the self-renewal capacity of ovarian CSCs that survived resveratrol treatment. Conclusion: Our findings not only shed light on a novel mechanism of action for resveratrol but also suggest that resveratrol, or its analogs, may be useful for CSC-directed therapy against ovarian cancer. ER -