TY - JOUR T1 - <em>Akt1</em> rs2498801 Is Related to Survival in Head and Neck Squamous Cell Cancer Treated with Radiotherapy JF - Anticancer Research JO - Anticancer Res SP - 269 LP - 271 VL - 35 IS - 1 AU - FRANCESCO PASQUALETTI AU - GUIDO BOCCI AU - VALENTINA MEY AU - VALENTINA MENGHINI AU - SABRINA MONTRONE AU - PAOLA COCUZZA AU - PATRIZIA FERRAZZA AU - VERONICA SECCIA AU - DURIM DELISHAJ AU - CINZIA ORLANDINI AU - MARIA GRAZIA FABRINI AU - ROMANO DANESI Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/269.abstract N2 - Background: Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. Materials and Methods: Data relating to Akt1 single nucleotide polymorphism (SNP) and response to treatment of 46 patients treated with exclusive RT or RT-CT for HNSCC were evaluated. Results: For heterozygous patients median overall survival was 28.5 months, while for the wild-type group median overall survival was 10.9 (p=0.019). Three-year survival was 85% for mutated Akt1 homozygosis and 40% for patients with a heterozygous status (p=0.019, hazard ratio (HR)=7.960). Conclusion: SNP of rs2498804 can recognize patients resistant to RT-CT. Further studies are needed to confirm our data and to investigate the role of Akt SNPs in HNSCC patients. ER -