TY - JOUR T1 - Clinical Significance of Adjuvant Surgery Following Chemotherapy for Patients with Initially Unresectable Stage IV Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 401 LP - 406 VL - 35 IS - 1 AU - SHUHEI ITO AU - EIJI OKI AU - YUICHIRO NAKASHIMA AU - KOJI ANDO AU - YUKIHARU HIYOSHI AU - KIPPEI OHGAKI AU - HIROSHI SAEKI AU - MASARU MORITA AU - YOSHIHISA SAKAGUCHI AU - YOSHIHIKO MAEHARA Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/401.abstract N2 - Background: More effective treatment is necessary to improve the poor prognosis for patients with unresectable gastric cancer. We investigated the efficacy and feasibility of adjuvant surgery following chemotherapy. Patients and Methods: Records of 70 patients with unresectable stage IV gastric cancer who underwent induction chemotherapy were reviewed retrospectively. Patients who developed an absence of non-curative clinical factors during chemotherapy underwent gastrectomy [adjuvant surgery (AS) group]; the others continued chemotherapy [non-AS group]. Results: Non-AS and AS groups contained 56 (80%) and 14 (20%) patients, respectively. In the AS group, 92.9% of patients had one non-curative clinical factor, while 48.2% of patients in the non-AS group had two or more non-curative clinical factors (p=0.0386). In the AS group, operative outcomes, including the postoperative complication rate (21.4%), were acceptable. The 3-year overall survival rate in the AS group was 65.6% versus 7.7% in the non-AS group (p<0.0001). In patients with one non-curative clinical factor of peritoneal dissemination, the median survival of the AS group was 29.5 months versus 11.4 months in the non-AS group (p=0.0230). Conclusion: Adjuvant surgery for initially unresectable stage IV gastric cancer was safe and feasible, and may improve the prognosis for patients with one non-curative clinical factor, such as peritoneal dissemination. ER -