RT Journal Article SR Electronic T1 Sunitinib-induced Thyrotoxicosis – A not so Rare Entity JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 481 OP 485 VO 35 IS 1 A1 MARIJANA JAZVIĆ A1 MARIN PRPIĆ A1 TOMISLAV JUKIĆ A1 JURE MURGIĆ A1 BLANKA JAKŠIĆ A1 DAVOR KUST A1 ANGELA PRGOMET A1 ANTE BOLANČA A1 ZVONKO KUSIĆ YR 2015 UL http://ar.iiarjournals.org/content/35/1/481.abstract AB Background/Aim: The tyrosine kinase inhibitor (TKI) sunitinib malate is nowadays a standard first-line treatment option for patients with metastatic clear-cell renal cell carcinoma (mRCC). The aim of this study was to evaluate the incidence and clinical course of thyrotoxicosis in our cohort of patients treated with sunitinib. Patients and Methods: Medical records of all patients treated with first-line sunitinib for mRCC at our Institution between November 2008 and March 2014 were retrospectively reviewed. Thyroid function was assessed after every 2 cycles of therapy, during the 2 weeks off period. Results: Out of the 62 included patients, hypothyroidism has developed during therapy in 12 patients (19%) and it was preceded by thyrotoxicosis in 2 (3.2%). Conclusion: Sunitinib-induced thyrotoxicosis (SIT), a not so rare entity, was followed by hypothyroidism. The patterns of occurrence and possible significance of SIT, as predictive marker of better treatment response to sunitinib, need to be validated in further studies.