TY - JOUR T1 - Benefit of Neoadjuvant Chemotherapy for Siewert Type II Esophagogastric Junction Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 419 LP - 425 VL - 35 IS - 1 AU - KEI HOSODA AU - KEISHI YAMASHITA AU - NATSUYA KATADA AU - HIROMITSU MORIYA AU - HIROAKI MIENO AU - SHINICHI SAKURAMOTO AU - SHIRO KIKUCHI AU - MASAHIKO WATANABE Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/419.abstract N2 - Aim: Our objective was to clarify if preoperative chemotherapy was associated with improved survival in Japanese patients with Siewert type II adenocarcinoma of the esophagogastric junction. Patients and Methods: We retrospectively reviewed the medical records of 86 patients with Siewert type II adenocarcinoma who underwent R0 resection at the Kitasato University between 1997 and 2013. Cox regression analysis using a backward stepwise selection method was performed to identify independent prognostic factors for relapse-free survival (RFS). Results: The median age was 67 years. The male:female ratio was 74:12. Right thoracic, left thoracic and transhiatal approaches were performed in 10, 10 and 66 patients, respectively, and perioperative transfusion in 16 patients. Preoperative chemotherapy was administered to 19 patients; out of these, 13 received chemotherapy using the DCS regimen (docetaxel 40 mg/m2, day 1; cisplatin 60 mg/m2, day 1; S-1 80-120 mg/body, days 1-14; every 28 days). A median of three cycles of preoperative DCS chemotherapy were used. Histological responses of 1b, 2, 3 and unknown grades were obtained in three, three, four and three patients, respectively. The 5-year RFS rate was 55%, and the median follow-up period was 36 months. Cox regression analysis regarding RFS identified (y)pN1-3 [hazard ratio (HR)=4.44; 95% confidence interval (CI)=1.98-11.27], performance of perioperative transfusion (HR=4.71; 95% CI=1.69-11.88) and no preoperative chemotherapy (HR=3.75; 95% CI=1.22-14.26) as significant and independent indicators of poor prognosis. Conclusion: Preoperative chemotherapy using DCS is potentially beneficial for Japanese patients with Siewert type II adenocarcinoma. Further prospective clinical studies are required to confirm our findings. ER -