PT  - JOURNAL ARTICLE
AU  - ARLETTE RWIGEMERA
AU  - JEAN MAMELONA
AU  - LUC J. MARTIN
TI  - Comparative Effects Between Fucoxanthinol and its Precursor Fucoxanthin on Viability and Apoptosis of Breast Cancer Cell Lines MCF-7 and MDA-MB-231
DP  - 2015 Jan 01
TA  - Anticancer Research
PG  - 207--219
VI  - 35
IP  - 1
4099  - http://ar.iiarjournals.org/content/35/1/207.short
4100  - http://ar.iiarjournals.org/content/35/1/207.full
SO  - Anticancer Res2015 Jan 01; 35
AB  - Background/Aim: We evaluated whether low doses of the natural carotenoid fucoxanthin and/or of its metabolite fucoxanthinol are effective against proliferation of estrogen-sensitive MCF-7 and estrogen-resistant MDA-MB-231 breast cancer cell lines. Materials and Methods: These cell lines were stimulated with 10 to 20 μM fucoxanthin and/or fucoxanthinol, followed by cell viability assays, Annexin V immunofluorescence to evaluate apoptosis, as well as mRNA and protein extractions for changes in nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) members' expressions and nuclear translocations. Results: Fucoxanthin and fucoxanthinol reduced the viability of MCF-7 and MDA-MB-231 cells in a time-dependent manner as a result of increased apoptosis. In both cell lines, modulatory actions of fucoxanthinol on members of the NF-κB pathway were more pronounced than that of fucoxanthin. Conclusion: In MDA-MB-231 cells, fucoxanthinol reduced nuclear levels of NF-κB members' p65, p52 and RelB. Fucoxanthinol and fucoxanthin could be effective for the treatment and/or prevention of breast cancer.