TY - JOUR T1 - Oil Palm Phenolics (OPP) Inhibit Pancreatic Cancer Cell Proliferation <em>via</em> Suppression of NF-κB Pathway JF - Anticancer Research JO - Anticancer Res SP - 97 LP - 106 VL - 35 IS - 1 AU - XIANGMING JI AU - ANEE USMAN AU - NURUL H. RAZALLI AU - RAVIGADEVI SAMBANTHAMURTHI AU - SMITI V. GUPTA Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/97.abstract N2 - Background: Oil palm phenolics (OPP) or Palm Juice (PJ), a water soluble extract from the palm fruit (Elaies guineensis) has been documented to have anti-carcinogenic activities in various cancer types. Materials and Methods: To investigate OPP effects in pancreatic cancer (PaCa) cells, two PaCa cell lines (PANC-1 and BxPC-3) were treated with different OPP doses. The anti-proliferative, apoptotic and anti-invasive properties of OPP were evaluated using MTS, cytoplasmic histone-DNA fragmentation and matrigel invasive assays, respectively. Results: OPP suppressed PaCa proliferation in a dose-dependent manner. Its anti-invasive effects were validated by decreased expressions of MMP-9 and VEGF. Cell-cycle analysis demonstrated that cells were arrested in the S phase. OPP-induced apoptosis was associated with decrease in survivin and Bcl-XL expressions and increased expression of cleaved caspase-3, caspase-9 and PARP. Conclusion: Overall, our results demonstrate the anti-tumor effects of OPP on PaCa cells, providing initial evidence towards its potential therapeutic use. ER -