@article {JI97, author = {XIANGMING JI and ANEE USMAN and NURUL H. RAZALLI and RAVIGADEVI SAMBANTHAMURTHI and SMITI V. GUPTA}, title = {Oil Palm Phenolics (OPP) Inhibit Pancreatic Cancer Cell Proliferation via Suppression of NF-κB Pathway}, volume = {35}, number = {1}, pages = {97--106}, year = {2015}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Oil palm phenolics (OPP) or Palm Juice (PJ), a water soluble extract from the palm fruit (Elaies guineensis) has been documented to have anti-carcinogenic activities in various cancer types. Materials and Methods: To investigate OPP effects in pancreatic cancer (PaCa) cells, two PaCa cell lines (PANC-1 and BxPC-3) were treated with different OPP doses. The anti-proliferative, apoptotic and anti-invasive properties of OPP were evaluated using MTS, cytoplasmic histone-DNA fragmentation and matrigel invasive assays, respectively. Results: OPP suppressed PaCa proliferation in a dose-dependent manner. Its anti-invasive effects were validated by decreased expressions of MMP-9 and VEGF. Cell-cycle analysis demonstrated that cells were arrested in the S phase. OPP-induced apoptosis was associated with decrease in survivin and Bcl-XL expressions and increased expression of cleaved caspase-3, caspase-9 and PARP. Conclusion: Overall, our results demonstrate the anti-tumor effects of OPP on PaCa cells, providing initial evidence towards its potential therapeutic use.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/35/1/97}, eprint = {https://ar.iiarjournals.org/content/35/1/97.full.pdf}, journal = {Anticancer Research} }