RT Journal Article SR Electronic T1 Prognostic Impact of Central Nervous System Metastases After Acquired Resistance to EGFR-TKI: Poorer Prognosis Associated with T790M-negative Status and Leptomeningeal Metastases JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1025 OP 1031 VO 35 IS 2 A1 AKITO HATA A1 NOBUYUKI KATAKAMI A1 HIROSHIGE YOSHIOKA A1 JUMPEI TAKESHITA A1 KOSUKE TANAKA A1 KATSUHIRO MASAGO A1 SHIRO FUJITA A1 REIKO KAJI A1 YUKIHIRO IMAI A1 KAZUYA MONDEN A1 TAKESHI MATSUMOTO A1 KAZUMA NAGATA A1 KYOKO OTSUKA A1 RYO TACHIKAWA A1 KEISUKE TOMII A1 KEI KUNIMASA A1 MASAHIRO IWASAKU A1 AKIHIRO NISHIYAMA A1 TADASHI ISHIDA A1 YOSHIHIRO NISHIMURA YR 2015 UL http://ar.iiarjournals.org/content/35/2/1025.abstract AB Aim: The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). Patients and Methods: We defined CNS-collapse as death due to uncontrolled and progressive CNS metastases. Post-progression survival (PPS) after initial TKI failure and T790M status were retrospectively compared in 92 patients with or without CNS collapse. Results: The median PPS in 32 patients with CNS-collapse (16.7 months) was significantly shorter than that of 60 without (26.8 months) (p=0.0002). T790M was detected in four (12%) out of the 32 CNS-collapse patients and in 26 (43%) out of 60 without (p=0.0026). Median PPS in 39 patients with leptomeningeal metastases (LM) (11.4 months) was significantly shorter versus 53 without (26.8 months) (p=0.0006). The median PPS was 25.1 months in 40 patients with brain metastases and 11.2 months in 52 without (p=0.0387). T790M was detected in 4/5 resected brain tumors (80%) and in 1/26 cerebrospinal fluid (CSF) samples (4%) (p=0.0008). Conclusion: CNS-collapse represented poorer prognosis, which was associated with T790M-negative status and LM. Controlling CNS metastases, especially LM, is important to achieve longer survival.