PT - JOURNAL ARTICLE AU - DESPOINA GEORGIADOU AU - THEODOROS N. SERGENTANIS AU - STRATIGOULA SAKELLARIOU AU - GEORGE M. FILIPPAKIS AU - FLORA ZAGOURI AU - THEODORA PSALTOPOULOU AU - ANDREAS C. LAZARIS AU - EFSTRATIOS PATSOURIS AU - ANTONIA GOUNARIS AU - GEORGE C. ZOGRAFOS TI - Immunohistochemical Expression of Sex Steroid Hormone Receptors, Cell Cycle Regulators and Angiogenesis Factors in Intraductal Papillary Mucinous Neoplasms: An Explorative Study DP - 2015 Feb 01 TA - Anticancer Research PG - 1049--1056 VI - 35 IP - 2 4099 - http://ar.iiarjournals.org/content/35/2/1049.short 4100 - http://ar.iiarjournals.org/content/35/2/1049.full SO - Anticancer Res2015 Feb 01; 35 AB - Aim: The objectives of our explorative study were to (i) evaluate the immunohistochemical expression of sex steroid hormone receptors (estrogen receptor a [ERα], estrogen receptor β [ERβ], progesterone receptor [PR] and androgen receptor [AR]), angiogenesis factors (vascular endothelial growth factor [VEGF] and inhibitor of differentiation/DNA synthesis 1 [Id-1]) and cell-cycle regulators (cyclin D1, p16 and p27) in intraductal papillary mucinous neoplasms (IPMNs) in comparison to normal adjacent pancreatic tissues and (ii) assess their correlation with the grade and histological sub-type of those lesions. Materials and Methods: Paraffin-embedded specimens from 12 consecutive patients with IPMNs were immunostained for the studied markers and staining quantification was assessed by an image analysis system. Results: AR H-score and cyclin D1 H-score were significantly higher in the IPMN lesions (0.86±0.33 vs. 0.57±0.12 in the normal tissue, p=0.010 and 0.47±0.23 vs. 0.21±0.20 in the normal tissue, p=0.019, respectively). No significant differences were noted regarding the expression of ERα, ERβ, PR, p16, p27, VEGF, Id-1 or MVD. Moreover, no significant associations were found between the expression of studied markers and grade or histological subtype. Conclusion: Our study showed higher expression of AR and cyclin D1 in IPMNs compared to normal pancreatic ducts without any association between AR and cyclin D1 expression and IPMNs' grade or subtype.