RT Journal Article SR Electronic T1 Inter- and Intra-observer Variability in Biopsy of Bone and Soft Tissue Sarcomas JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 961 OP 966 VO 35 IS 2 A1 HEINRICH M.L. MÜHLHOFER A1 ULRICH LENZE A1 FLORIAN LENZE A1 INA-CHRISTINE RONDAK A1 JOHANNES SCHAUWECKER A1 HANS RECHL A1 RUEDIGER VON EISENHART-ROTHE A1 FLORIAN POHLIG YR 2015 UL http://ar.iiarjournals.org/content/35/2/961.abstract AB Background/Aim: The aim of this study was to analyze the inter- and intra-observer variability regarding biopsy technique in bone and soft tissue sarcoma based on magnetic resonance imaging (MRI). Patients and Methods: Thirty-seven MRI scans of bone and soft tissue sarcomas treated in our clinic were randomly selected. Six observers with three different expertise levels were assigned to analyze the scans for suspected entity and preferred biopsy technique at 2 time points with a delay of 8 weeks. Results: The differentiation between bone and soft tissue sarcomas in MRI seemed closely related to the observer's level of experience. Regarding biopsy technique, no inter-observer accordance could be identified in either group. Conclusion: We observed an association of inter- and intra-observer agreement regarding suspected tumor entity and the observer's level of experience. The decision for either biopsy technique showed a low inter-observer but high intra-observer variability. These findings suggest that the decision for incisional or core needle biopsy is, even in the expert group, frequently based on personal predilection.