RT Journal Article SR Electronic T1 Patient-derived Orthotopic Xenograft (PDOX) Nude Mouse Model of Soft-tissue Sarcoma More Closely Mimics the Patient Behavior in Contrast to the Subcutaneous Ectopic Model JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 697 OP 701 VO 35 IS 2 A1 YUKIHIKO HIROSHIMA A1 YONG ZHANG A1 NAN ZHANG A1 FUMINARI UEHARA A1 ALI MAAWY A1 TAKASHI MURAKAMI A1 SUMIYUKI MII A1 MAKO YAMAMOTO A1 SHINJI MIWA A1 SHUYA YANO A1 MASASHI MOMIYAMA A1 RYUTARO MORI A1 RYUSEI MATSUYAMA A1 TAKASHI CHISHIMA A1 KUNIYA TANAKA A1 YASUSHI ICHIKAWA A1 MICHAEL BOUVET A1 ITARU ENDO A1 ROBERT M. HOFFMAN YR 2015 UL http://ar.iiarjournals.org/content/35/2/697.abstract AB Aim: Soft-tissue sarcomas are a group of rare mesenchymal carcinomas that include approximately 50 histological types, and account for 1% of all adult cancer cases. The yearly incidence of soft-tissue sarcomas in the USA is approximately 11,280 cases, with an overall mortality of 3,900 deaths per year. Materials and Methods: In this study, we established a patient-derived orthotopic xenograft (PDOX) from a patient with a soft-tissue sarcoma of the retroperitoneum in nude mice and compared it to a subcutaneous patient-derived model of the same tumor for histology. Results: In the PDOX model, a bulky tumor grew in the left retroperitoneum in the same manner as the patient's tumor. Upon histological examination, the majority of the PDOX tissue section comprised sarcomatous high-grade spindle cells of varying sizes, similar to the original patient tumor. In contrast, the majority of the subcutaneously-implanted tumor comprised round to oval cells. Conclusion: These results indicate that the PDOX recapitulated the histology of the original tumor more than the subcutaneous model.