RT Journal Article
SR Electronic
T1 Synthesis and Structure–Activity Relationship Studies of Furan-ring Fused Chalcones as Antiproliferative Agents
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 811
OP 817
VO 35
IS 2
A1 YUSUKE SAITO
A1 MAHO KISHIMOTO
A1 YUKO YOSHIZAWA
A1 SATORU KAWAII
YR 2015
UL http://ar.iiarjournals.org/content/35/2/811.abstract
AB As part of our continuing investigation of flavonoid derivatives as potential anticancer substances, the synthesis of 25 cinnamoyl derivatives of benzofuran as furan-fused chalcones was carried-out and these compounds were further evaluated for their antiproliferative activity towards HL60 promyelocytic leukemia cells. In comparison with 2’,4’-dihydroxychalcone, attachment of a furan moiety on the A-ring enhanced activity by more than twofold. Benzofurans may be useful in the design of biologically active flavonoids.