TY - JOUR T1 - Synthesis and Structure–Activity Relationship Studies of Furan-ring Fused Chalcones as Antiproliferative Agents JF - Anticancer Research JO - Anticancer Res SP - 811 LP - 817 VL - 35 IS - 2 AU - YUSUKE SAITO AU - MAHO KISHIMOTO AU - YUKO YOSHIZAWA AU - SATORU KAWAII Y1 - 2015/02/01 UR - http://ar.iiarjournals.org/content/35/2/811.abstract N2 - As part of our continuing investigation of flavonoid derivatives as potential anticancer substances, the synthesis of 25 cinnamoyl derivatives of benzofuran as furan-fused chalcones was carried-out and these compounds were further evaluated for their antiproliferative activity towards HL60 promyelocytic leukemia cells. In comparison with 2’,4’-dihydroxychalcone, attachment of a furan moiety on the A-ring enhanced activity by more than twofold. Benzofurans may be useful in the design of biologically active flavonoids. ER -