PT  - JOURNAL ARTICLE
AU  - PALMQVIST, TOMAS
AU  - DOS S.MATIAS, LUCÍLIO
AU  - MARTHINSEN, ANNE B.L.
AU  - SUNDSET, MARIT
AU  - WANDERÅS, ANNE D.
AU  - DANIELSEN, SIGNE
AU  - TOMA-DASU, IULIANA
TI  - Radiobiological Treatment Planning Evaluation of Inverse Planning Simulated Annealing for Cervical Cancer High-dose-rate Brachytherapy
DP  - 2015 Feb 01
TA  - Anticancer Research
PG  - 935--939
VI  - 35
IP  - 2
4099  - http://ar.iiarjournals.org/content/35/2/935.short
4100  - http://ar.iiarjournals.org/content/35/2/935.full
SO  - Anticancer Res2015 Feb 01; 35
AB  - Aim: To compare five inverse treatment plans with one conventional manually-optimized plan for cervical cancer brachytherapy (BT) using radiobiological parameters combined with dosimetric and volumetric parameters. Materials and Methods: Five inverse treatment plans were calculated using an inverse planning simulated annealing (IPSA) algorithm for each of four fractions for 12 cervical cancer patients treated with high-dose-rate (HDR) brachytherapy. The inverse treatment plans were compared to a manually-optimized plan used for the actual treatment of the patients. The comparison of the plans was performed with respect to the probability of cure without complication (P+). Results: Overall, the manually optimized plan scored the best results; however, the probability of cure without complication is within an acceptable clinical range for all the plans. Conclusion: Although there are still considerable uncertainties in the radiobiological parameters, the radiobiological plan evaluation method presents itself as a potential complement to physical dosimetric methods.