TY - JOUR T1 - Comparative Analysis of Tumor Angiogenesis and Clinical Features of 55 Cases of Pleomorphic Carcinoma and Adenocarcinoma of the Lung JF - Anticancer Research JO - Anticancer Res SP - 389 LP - 394 VL - 35 IS - 1 AU - YUKARI TSUBATA AU - AKIHISA SUTANI AU - TAMIO OKIMOTO AU - ISAO MURAKAMI AU - RYOSUKE USUDA AU - TSUNEO OKUMICHI AU - SEI-ICHI KAKEGAWA AU - KEN-ICHI TOGASHI AU - SHINJI KOSAKA AU - YOSHINORI YAMASHITA AU - KOJI KISHIMOTO AU - TAKASHIGE KURAKI AU - TAKESHI ISOBE Y1 - 2015/01/01 UR - http://ar.iiarjournals.org/content/35/1/389.abstract N2 - Background/Aim: Pleomorphic carcinoma (PC) of the lung is a rare tumor that usually has an aggressive clinical course and a poor prognosis. Clinical and pathological features remain unclear. The aim of this study was to determine whether tumor angiogenesis of PC is up-regulated compared to that in adenocarcinoma (AD). Materials and Methods: We collected 55 cases of PC and AD in which the patients had undergone either lung resection or autopsy and immunohistochemically examined the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor (HIF)-1α and microvessel density (MVD) in tissue specimens. Results: VEGF was expressed in many cases of both PC and AD with no significant differences between the groups. In contrast, the expression of HIF-1α and MVD were significantly greater in PC than AD. Median survival time of the PC group was 14.7 months and significantly shorter than that of the AD group. Conclusion: MVD and expression of HIF-1α are associated with angiogenesis in PC and confer a poorer prognosis. Tumor angiogenesis provides significant prognostic information regarding clinical outcome in patients with PC. ER -