PT  - JOURNAL ARTICLE
AU  - YUKARI TSUBATA
AU  - AKIHISA SUTANI
AU  - TAMIO OKIMOTO
AU  - ISAO MURAKAMI
AU  - RYOSUKE USUDA
AU  - TSUNEO OKUMICHI
AU  - SEI-ICHI KAKEGAWA
AU  - KEN-ICHI TOGASHI
AU  - SHINJI KOSAKA
AU  - YOSHINORI YAMASHITA
AU  - KOJI KISHIMOTO
AU  - TAKASHIGE KURAKI
AU  - TAKESHI ISOBE
TI  - Comparative Analysis of Tumor Angiogenesis and Clinical Features of 55 Cases of Pleomorphic Carcinoma and Adenocarcinoma of the Lung
DP  - 2015 Jan 01
TA  - Anticancer Research
PG  - 389--394
VI  - 35
IP  - 1
4099  - http://ar.iiarjournals.org/content/35/1/389.short
4100  - http://ar.iiarjournals.org/content/35/1/389.full
SO  - Anticancer Res2015 Jan 01; 35
AB  - Background/Aim: Pleomorphic carcinoma (PC) of the lung is a rare tumor that usually has an aggressive clinical course and a poor prognosis. Clinical and pathological features remain unclear. The aim of this study was to determine whether tumor angiogenesis of PC is up-regulated compared to that in adenocarcinoma (AD). Materials and Methods: We collected 55 cases of PC and AD in which the patients had undergone either lung resection or autopsy and immunohistochemically examined the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor (HIF)-1α and microvessel density (MVD) in tissue specimens. Results: VEGF was expressed in many cases of both PC and AD with no significant differences between the groups. In contrast, the expression of HIF-1α and MVD were significantly greater in PC than AD. Median survival time of the PC group was 14.7 months and significantly shorter than that of the AD group. Conclusion: MVD and expression of HIF-1α are associated with angiogenesis in PC and confer a poorer prognosis. Tumor angiogenesis provides significant prognostic information regarding clinical outcome in patients with PC.