RT Journal Article
SR Electronic
T1 Radiosurgery with 20 Gy Provides Better Local Contol of 1-3 Brain Metastases from Breast Cancer than with Lower Doses
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 333
OP 336
VO 35
IS 1
A1 RADES, DIRK
A1 HUTTENLOCHER, STEFAN
A1 RUDAT, VOLKER
A1 HORNUNG, DAGMAR
A1 BLANCK, OLIVER
A1 PHUONG, PHAM CAM
A1 KHOA, MAI TRONG
A1 SCHILD, STEVEN E.
A1 FISCHER, DOROTHEA
YR 2015
UL http://ar.iiarjournals.org/content/35/1/333.abstract
AB Aim: To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer. Patients and Methods: Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated. Results: Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60%, respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40%, respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10). Conclusion: Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.