PT  - JOURNAL ARTICLE
AU  - JENNY ÖHMAN
AU  - RAKEEBA MOWJOOD
AU  - LENA LARSSON
AU  - ANIKÓ KOVACS
AU  - BENGT MAGNUSSON
AU  - GÖRAN KJELLER
AU  - MATS JONTELL
AU  - BENGT HASSEUS
TI  - Presence of CD3-Positive T-Cells in Oral Premalignant Leukoplakia Indicates Prevention of Cancer Transformation
DP  - 2015 Jan 01
TA  - Anticancer Research
PG  - 311--317
VI  - 35
IP  - 1
4099  - http://ar.iiarjournals.org/content/35/1/311.short
4100  - http://ar.iiarjournals.org/content/35/1/311.full
SO  - Anticancer Res2015 Jan 01; 35
AB  - Aim: Leukoplakias (LPLs) are lesions in the oral mucosa that have a potential to transform into oral squamous cell carcinoma (OSCC). As the degree of immunosurveillance may be important for this transformation to occur, the aim of this study was to determine the presence of immune cells in LPLs with dysplasia in relation to later development of OSCC. Materials and Methods: Biopsies from 16 patients with clinical diagnosis of LPL and histopathological diagnosis of hyperkeratosis with dysplasia were immunostained with antibodies to detect CD3+ T cells, CD1a+ LCs, Ki-67+ and p53-expressing cells. Patients were divided into two groups: LPL with dysplasia that transformed into OSCC (LPL-dys) and that which did not (LPL-ca). Results: Quantitative analyses showed significantly lower numbers of CD3+ T-cells in LPL-ca than in LPL-dys. No significant differences were detected when comparing LPL-dys and LPL-ca regarding CD1a+, p53+ and Ki-67+ cells. Conclusion: The number of CD3-expressing T-cells may be important for preventing malignant transformation of LPL.