@article {SOHDA7473, author = {MAKOTO SOHDA and TATSUYA MIYAZAKI and HIROAKI HONJYO and KEIGO HARA and DAIGO OZAWA and SHIGEMASA SUZUKI and NARITAKA TANAKA and AKIHIKO SANO and MAKOTO SAKAI and TAKEHIKO YOKOBORI and MASANOBU NAKAJIMA and MINORU FUKUCHI and HIROYUKI KATO and TETSUYA HIGUCHI and YOSHITO TSUSHIMA and HIROYUKI KUWANO}, title = {L-[3-18F]-α-Methyltyrosine Uptake by Lymph Node Metastasis Is a Predictor of Complete Response to CRT in Esophageal Cancer}, volume = {34}, number = {12}, pages = {7473--7477}, year = {2014}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: The amino acid positron emission tomography (PET) tracer [18F]-3-fluoro-alpha-methyltyrosine (18F-FAMT) is known to be highly specific for malignancies. We evaluated the accumulation of 18F-FDG or 18F-FAMT in lymph nodes (LN) prior to definitive chemoradiotherapy (CRT) for esophageal cancer. Patients and Methods: We retrospectively reviewed 30 patients with esophageal squamous cell carcinoma. All patients received definitive CRT. The relationship between the accumulation of 18F-FDG PET or 18F-FAMT PET in LNs prior to CRT and clinical outcomes was assessed. Results: A correlation was observed between LNs in which most of 18F-FAMT was accumulated and complete response (CR) rate, but was not for 18F-FDG. Additionally, for 18F-FAMT, the CR rate was significantly higher in the LN accumulated lesion <=1 group than in the LN accumulated lesion \>2 group. Discussion: To predict the outcome of definitive CRT in patients with esophageal cancer, it is important to evaluate the LN status.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/34/12/7473}, eprint = {https://ar.iiarjournals.org/content/34/12/7473.full.pdf}, journal = {Anticancer Research} }