RT Journal Article
SR Electronic
T1 A Case Series of Patients with HER2-Overexpressed Primary Metastatic Gastroesophageal Adenocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 7357
OP 7360
VO 34
IS 12
A1 PELIN CINAR
A1 SARAH M. CALKINS
A1 ALAN P. VENOOK
A1 ROBIN K. KELLEY
YR 2014
UL http://ar.iiarjournals.org/content/34/12/7357.abstract
AB Background: Overexpression of the human epidermal growth factor 2 (HER2) is associated with an aggressive metastatic phenotype in patients with breast cancer but its prognostic impact is not well-characterized in gastroesophageal adenocarcinoma. Patients and Methods: This is a retrospective series of three cases of HER2-positive gastroesophageal cancer. Results: In this case series, we describe three patients presenting with widespread metastatic disease prior to development of symptoms from the primary tumor. Two patients presented with brain metastases, while one demonstrated lymphangitic spread to lungs. Conclusion: Pooled analyses of outcomes among sub-populations of contemporary trials are needed to better understand the natural history and prognostic impact of HER2 over-expression in patients with gastroesophageal cancers.