TY - JOUR T1 - Overexpression of the <em>ITGAV</em> Gene Is Associated with Progression and Spread of Colorectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 5599 LP - 5607 VL - 34 IS - 10 AU - JAQUES WAISBERG AU - LUCIANO DE SOUZA VIANA AU - RENATO JOSÉ AFFONSO JUNIOR AU - SANDRA REGINA MORINI SILVA AU - MARCOS VINICIUS ARAUJO DENADAI AU - FERNANDO BEANI MARGEOTTO AU - CAROLINA SALINAS DE SOUZA AU - DELCIO MATOS Y1 - 2014/10/01 UR - http://ar.iiarjournals.org/content/34/10/5599.abstract N2 - Background/Aim: The interaction of neoplastic cells with the extracellular matrix is a critical event for the initiation of cancer invasion and metastasis. We evaluated the relationship between the expression of SPARC, ITGAV, THBS1 and VCAM-1 genes of extracellular matrix in the progression and dissemination of colorectal cancer (CRC). Patients and Methods: Adult patients (N=114) underwent resection of CRC. Gene expression in CRC was determined by quantitative real-time polymerase chain reaction (PCR). Protein expression was analyzed by immunohistochemistry (IHC). Correlation with pathway-related molecules (p53, Bcl-2, Ki-67, EGFR and VEGF) was assessed. Results: Tumors with perineural invasion showed overexpression (p=0.028) of the ITGAV gene with regard to cancers without perineural invasion and validation of the result through IHC expression of the corresponding proteins, was significant for the expression of ITGAV protein (p=0.001). Conclusion: The overexpression of ITGAV gene was associated with higher progression and spread of CRC via perineural invasion. ER -