TY - JOUR T1 - Kinetics of Circulating Levels of miR-195, miR-155 and miR-21 in Patients with Breast Cancer Undergoing Mastectomy JF - Anticancer Research JO - Anticancer Res SP - 7443 LP - 7447 VL - 34 IS - 12 AU - MARIA IGGLEZOU AU - KATERINA VARELI AU - GEORGIOS K. GEORGIOU AU - IOANNIS SAINIS AU - EVANGELOS BRIASOULIS Y1 - 2014/12/01 UR - http://ar.iiarjournals.org/content/34/12/7443.abstract N2 - Background: MicroRNAs are small RNA molecules that negatively regulate the expression of the majority of proteins, mainly at the post-transcriptional level. Being stable in the circulation and resistant to storage handling, they are potentially promising biomarkers. Materials and Methods: We measured RNA levels of three microRNAs with tumorigenic or angiogenic potential (miR-155, miR-195, and miR-21) in blood samples taken from patients with early breast cancer, both preoperatively and postoperatively. Results: We found that persistently elevated postoperative levels of miR-195 were detected only in patients who developed early tumor relapse and that miR-155 levels tended to increase three days postoperatively (p=0.05) and fell below baseline one month post-surgery (p<0.05). We had no major findings for miR-21. Conclusion: The results of this pilot study indicate a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer. ER -