@article {IGGLEZOU7443, author = {MARIA IGGLEZOU and KATERINA VARELI and GEORGIOS K. GEORGIOU and IOANNIS SAINIS and EVANGELOS BRIASOULIS}, title = {Kinetics of Circulating Levels of miR-195, miR-155 and miR-21 in Patients with Breast Cancer Undergoing Mastectomy}, volume = {34}, number = {12}, pages = {7443--7447}, year = {2014}, publisher = {International Institute of Anticancer Research}, abstract = {Background: MicroRNAs are small RNA molecules that negatively regulate the expression of the majority of proteins, mainly at the post-transcriptional level. Being stable in the circulation and resistant to storage handling, they are potentially promising biomarkers. Materials and Methods: We measured RNA levels of three microRNAs with tumorigenic or angiogenic potential (miR-155, miR-195, and miR-21) in blood samples taken from patients with early breast cancer, both preoperatively and postoperatively. Results: We found that persistently elevated postoperative levels of miR-195 were detected only in patients who developed early tumor relapse and that miR-155 levels tended to increase three days postoperatively (p=0.05) and fell below baseline one month post-surgery (p\<0.05). We had no major findings for miR-21. Conclusion: The results of this pilot study indicate a possible involvement of miR-155 in surgery-induced angiogenesis and potential prognostic significance of high postoperative levels of circulating miR-195 in patients with breast cancer.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/34/12/7443}, eprint = {https://ar.iiarjournals.org/content/34/12/7443.full.pdf}, journal = {Anticancer Research} }