RT Journal Article SR Electronic T1 Interleukin-10 (IL-10) Promoter Genotypes Are Associated with Lung Cancer Risk in Taiwan Males and Smokers JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 7039 OP 7044 VO 34 IS 12 A1 TE-CHUN HSIA A1 WEN-SHIN CHANG A1 SHINN-JYE LIANG A1 WEI-CHUN CHEN A1 CHIH-YEN TU A1 HUNG-JEN CHEN A1 MEI-DUE YANG A1 CHIA-WEN TSAI A1 CHIN-MU HSU A1 CHANG-HAI TSAI A1 DA-TIAN BAU YR 2014 UL http://ar.iiarjournals.org/content/34/12/7039.abstract AB Interleukin-10 (IL-10) is an immunosuppressive cytokine involved in carcinogenesis via immune escape. The present study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Associations of three IL-10 polymorphic genotypes with lung cancer risk were investigated among 358 lung cancer patients and 716 age- and gender-matched healthy controls. In addition, the genetic-lifestyle interaction was also examined. The results showed that the percentages of TT, TC and CC for IL-10 T-819C genotypes were differentially represented as 59.2%, 35.8% and 5.0% in the lung-cancer patient group and 52.0%, 37.0% and 11.0% in the non-cancer control group, respectively (p for trend=0.0025). The CC genotype carriers were of lower risk for lung cancer (OR=0.4, 95% CI=0.23-0.69, p=0.0005). Further stratification of the population by gender and smoking behavior showed that the IL-10 T-819C genotype conducted a protective effect on lung cancer susceptibility, which was obvious among males and smokers (p=0.0003 and 0.0004, respectively). The CC and TC genotypes of IL-10 T-819C compared to the TT genotype may have a protective effect on lung cancer risk in Taiwan, particularly among males and smokers.