PT  - JOURNAL ARTICLE
AU  - TE-CHUN HSIA
AU  - WEN-SHIN CHANG
AU  - SHINN-JYE LIANG
AU  - WEI-CHUN CHEN
AU  - CHIH-YEN TU
AU  - HUNG-JEN CHEN
AU  - MEI-DUE YANG
AU  - CHIA-WEN TSAI
AU  - CHIN-MU HSU
AU  - CHANG-HAI TSAI
AU  - DA-TIAN BAU
TI  - Interleukin-10 (<em>IL-10</em>) Promoter Genotypes Are Associated with Lung Cancer Risk in Taiwan Males and Smokers
DP  - 2014 Dec 01
TA  - Anticancer Research
PG  - 7039--7044
VI  - 34
IP  - 12
4099  - http://ar.iiarjournals.org/content/34/12/7039.short
4100  - http://ar.iiarjournals.org/content/34/12/7039.full
SO  - Anticancer Res2014 Dec 01; 34
AB  - Interleukin-10 (IL-10) is an immunosuppressive cytokine involved in carcinogenesis via immune escape. The present study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Associations of three IL-10 polymorphic genotypes with lung cancer risk were investigated among 358 lung cancer patients and 716 age- and gender-matched healthy controls. In addition, the genetic-lifestyle interaction was also examined. The results showed that the percentages of TT, TC and CC for IL-10 T-819C genotypes were differentially represented as 59.2%, 35.8% and 5.0% in the lung-cancer patient group and 52.0%, 37.0% and 11.0% in the non-cancer control group, respectively (p for trend=0.0025). The CC genotype carriers were of lower risk for lung cancer (OR=0.4, 95% CI=0.23-0.69, p=0.0005). Further stratification of the population by gender and smoking behavior showed that the IL-10 T-819C genotype conducted a protective effect on lung cancer susceptibility, which was obvious among males and smokers (p=0.0003 and 0.0004, respectively). The CC and TC genotypes of IL-10 T-819C compared to the TT genotype may have a protective effect on lung cancer risk in Taiwan, particularly among males and smokers.