RT Journal Article SR Electronic T1 Portal Vein Embolisation with Application of Haematopoietic Stem Cells in Patients with Primarily or Non-resectable Colorectal Liver Metastases JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 7279 OP 7285 VO 34 IS 12 A1 VLADISLAV TRESKA A1 VACLAV LISKA A1 JAKUB FICHTL A1 DANIEL LYSAK A1 HYNEK MIRKA A1 JAN BRUHA A1 PETR DURAS A1 INKA TRESKOVA A1 JAKUB NAHLIK A1 VACLAV SIMANEK A1 ONDREJ TOPOLCAN YR 2014 UL http://ar.iiarjournals.org/content/34/12/7279.abstract AB Background: Insufficient future liver remnant volume (FLRV) is the main cause of low resectability of liver metastases from colorectal cancer (CLMs). One option for enhancing FLVR growth is the use of portal vein embolisation (PVE) with the application of autologous haematopoietic stem cells (HSCs). Patients and Methods: PVE with the application of HSCs was used in 11 patients (group 1) with primarily non-resectable CLMs due to insufficient FLRV without signs of extrahepatic metastases. The control group (group 2) consisted of 14 patients in whom only PVE was performed. We evaluated the product quality, FLRV growth, CLM volume, median survival and progression-free survival (PFS). Results: Product quality was achieved in all collections. In all group-I patients, sufficient FLRV growth occurred within three weeks. In the first and second weeks, FLRV increased optimally in most patients (p<0.006). In 13 out of the 14 group-2 patients, optimum FLVR growth was observed within three weeks following PVE (p<0.002). More rapid FLVR growth was observed in group 1 patients (p<0.01). CLM volume was significantly increased in both the group-2 (p<0.0005) and group-1 (p<0.008) patients at the time of liver resection. There was no significant difference in the growth of the CLM volume between the groups (p<0.18). The median survival was 7.3 and 6.8 months for group 1 and 2 patients, respectively, and the two-year PFS was 28% and 22% (p<0.18), respectively. Conclusion: PVE with HSC application is a promising method for effectively stimulating FLRV growth in patients with primarily non-resectable CLMs.