RT Journal Article
SR Electronic
T1 Increase of Peripheral Blood CD57<sup>+</sup> T-Cells in Patients with Oral Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5729
OP 5734
VO 34
IS 10
A1 IIDA, MASAKI
A1 TAKAYAMA, EIJI
A1 NAGANAWA, KOSUKE
A1 MITSUDO, KENJI
A1 ADACHI, MAKOTO
A1 BABA, JUN-ICHI
A1 FUJIMOTO-MUTO, MASAKO
A1 MOTOHASHI, MASAYUKI
A1 MIZUNO-KAMIYA, MASAKO
A1 KAWAKI, HARUMI
A1 KIOI, MITOMU
A1 ICHINOSE, MASAO
A1 SUMITOMO, SHIN-ICHIRO
A1 MURAMATSU, YASUNORI
A1 SHIKIMORI, MICHIO
A1 TOHNAI, IWAI
A1 KONDOH, NOBUO
YR 2014
UL http://ar.iiarjournals.org/content/34/10/5729.abstract
AB Background/Aim: The subset of T-cells positive for expression of cluster of differentiation (CD) 57 has been associated with various cancer phenotypes. However, the presence of CD57+ T-cells in patients with oral squamous cell carcinoma (OSCC) has yet to be confirmed. In the present study, we examined the diagnostic significance of the presence of CD57+ T-cells in peripheral blood (PB) from patients with OSCC. Materials and Methods: The subset of CD57+ T-cells in PB was analyzed in 43 patients with OSCC by fluorescence-activated cell sorting (FACS) analysis. Results: The proportion of CD57+ T-cells, including both CD8+ and CD4+ subsets, significantly increased with clinical stage, especially in parallel with tumor size. Conclusion: Our results suggest that an increase in the population of CD57+ T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC.