PT  - JOURNAL ARTICLE
AU  - IIDA, MASAKI
AU  - TAKAYAMA, EIJI
AU  - NAGANAWA, KOSUKE
AU  - MITSUDO, KENJI
AU  - ADACHI, MAKOTO
AU  - BABA, JUN-ICHI
AU  - FUJIMOTO-MUTO, MASAKO
AU  - MOTOHASHI, MASAYUKI
AU  - MIZUNO-KAMIYA, MASAKO
AU  - KAWAKI, HARUMI
AU  - KIOI, MITOMU
AU  - ICHINOSE, MASAO
AU  - SUMITOMO, SHIN-ICHIRO
AU  - MURAMATSU, YASUNORI
AU  - SHIKIMORI, MICHIO
AU  - TOHNAI, IWAI
AU  - KONDOH, NOBUO
TI  - Increase of Peripheral Blood CD57<sup>+</sup> T-Cells in Patients with Oral Squamous Cell Carcinoma
DP  - 2014 Oct 01
TA  - Anticancer Research
PG  - 5729--5734
VI  - 34
IP  - 10
4099  - http://ar.iiarjournals.org/content/34/10/5729.short
4100  - http://ar.iiarjournals.org/content/34/10/5729.full
SO  - Anticancer Res2014 Oct 01; 34
AB  - Background/Aim: The subset of T-cells positive for expression of cluster of differentiation (CD) 57 has been associated with various cancer phenotypes. However, the presence of CD57+ T-cells in patients with oral squamous cell carcinoma (OSCC) has yet to be confirmed. In the present study, we examined the diagnostic significance of the presence of CD57+ T-cells in peripheral blood (PB) from patients with OSCC. Materials and Methods: The subset of CD57+ T-cells in PB was analyzed in 43 patients with OSCC by fluorescence-activated cell sorting (FACS) analysis. Results: The proportion of CD57+ T-cells, including both CD8+ and CD4+ subsets, significantly increased with clinical stage, especially in parallel with tumor size. Conclusion: Our results suggest that an increase in the population of CD57+ T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC.