PT  - JOURNAL ARTICLE
AU  - ZORAN JUKIC
AU  - ZELJKO FERENCIC
AU  - PETRA RADULOVIC
AU  - AUGUST MIJIC
AU  - ALEKSANDRA FUCIC
TI  - Estrogen and Androgen Receptors in Inflammatory Fibroid Polyp (Vanek's Tumor): Case Report
DP  - 2014 Dec 01
TA  - Anticancer Research
PG  - 7203--7206
VI  - 34
IP  - 12
4099  - http://ar.iiarjournals.org/content/34/12/7203.short
4100  - http://ar.iiarjournals.org/content/34/12/7203.full
SO  - Anticancer Res2014 Dec 01; 34
AB  - Background/Aim: Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with inflammatory infiltrate. The aim of the present study was to investigate the presence of estrogen and androgen receptors in IFP and compare it with its proliferative loci. Patients and Methods: The study analyzed a 79-year-old patient suffering from IFP. Analyses were performed by immunohistochemistry. Results: Androgen-positive spindle cells were detected at the periphery of onion skin-like formations. Estrogen receptor-positive cells were not detected and Ki67 showed low proliferative activity. Conclusion: This case report shows for the first time the presence of androgen receptor-positive cells whose location corresponds with the distribution of Ki67-positive cells in IFP.