PT  - JOURNAL ARTICLE
AU  - YURI JEONG
AU  - JIN-HONG PARK
AU  - YOUNG-JOO LEE
AU  - KWANG-MIN PARK
AU  - SHIN HWANG
AU  - HEUNG-MOON CHANG
AU  - KYU-PYO KIM
AU  - SANG MIN YOON
AU  - NURI HYUN JUNG
AU  - JONG HOON KIM
TI  - Postoperative Radiotherapy for Gallbladder Cancer
DP  - 2014 Oct 01
TA  - Anticancer Research
PG  - 5621--5629
VI  - 34
IP  - 10
4099  - http://ar.iiarjournals.org/content/34/10/5621.short
4100  - http://ar.iiarjournals.org/content/34/10/5621.full
SO  - Anticancer Res2014 Oct 01; 34
AB  - Aim: To evaluate the results of postoperative radiotherapy (PORT) and to identify prognostic factors for gallbladder cancer (GBC). Patients and Methods: We retrospectively analyzed 86 patients with GBC who underwent potentially curative surgical resection and PORT between November 1993 and December 2009. All patients received three-dimensional conformal radiotherapy and 61 patients (71%) had concurrent chemotherapy. Survival outcomes including locoregional control (LRC), disease-free survival (DFS) and overall survival (OS) rates were analyzed. Results: The median follow-up period was 83 months for surviving patients. The 5-year OS, DFS and LRC rates were 42%, 36% and 73%, respectively. Isolated locoregional recurrence as first failure occurred in seven patients (8%). On multivariate analysis, the postoperative carbohydrate antigen 19-9 (CA 19-9) level was a significant prognostic factor for LRC, DFS and OS. Conclusion: Adjuvant radiotherapy might be an effective treatment in terms of LRC in GBC. Postoperative CA 19-9 might be useful as a surrogate marker for survival.