TY - JOUR T1 - Lectin Histochemistry of Murine WAP-T Mammary Cancer Reveals Similar Glycoconjugate Changes to Those in Human Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 7045 LP - 7053 VL - 34 IS - 12 AU - STEFFEN SCHREIBER AU - ANDREAS GOCHT AU - FLORIAN WEGWITZ AU - WOLFGANG DEPPERT AU - UDO SCHUMACHER Y1 - 2014/12/01 UR - http://ar.iiarjournals.org/content/34/12/7045.abstract N2 - Background: The WAP-T mouse model is an established clinically relevant model of breast cancer. Lectins have been used to study malignant progression in clinical studies. We investigated lectin binding sites to test for the clinical relevance of this model. Materials and Methods: Samples of the WAP-T mouse mammary tissues, from normal tissues to undifferentiated higher tumor grades were stained using an indirect technique with nine different lectins for intensity of lectin binding. Results: HPA bound to the luminal epithelium in higher tumor grades in a similar pattern to that in human breast cancer. BSA-IB4 bound to luminal epithelium in hyperplasia and increased towards higher grades, comparable to previous clinical studies. PHA-L-binding to myoepithelium and luminal epithelium increased from hyperplasia to higher grades, comparable to findings in human breast cancer. Conclusion: The results of our study support the hypothesis that lectin binding sites change similarly in WAP-T and human breast cancer, stressing the similarity of this model with the clinical setting. ER -