RT Journal Article SR Electronic T1 Predisposing Factors for Larynx Preservation Strategies with Non-surgical Multimodality Treatment for Locally Advanced (T3-4) Larynx, Hypopharynx and Cervical Esophageal Disease JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5205 OP 5210 VO 34 IS 9 A1 GEN SUZUKI A1 HIDEYA YAMAZAKI A1 ETSUYO OGO A1 TOSHI ABE A1 HIDEHIRO ETO A1 KOICHIRO MURAKI A1 CHIKAYUKI HATTORI A1 HIROHITO UMENO A1 NORIMITSU TANAKA A1 TOSHIAKI TANAKA A1 SATOAKI NAKAMURA A1 KEN YOSHIDA YR 2014 UL http://ar.iiarjournals.org/content/34/9/5205.abstract AB Aim: To identify predisposing factors for larynx preservation strategies using non-surgical multimodality approaches. Patients and Methods: We retrospectively reviewed the records of 48 patients with T3-4 diseases (14 larynx, 19 hypopharynx, 15 cervical esophagus). Out of 48 patients, 33 refused surgery, and 15 were deemed inoperable, and a total of 25 were graded as T3 and 23 as T4. A total of 24 patients received induction chemotherapy. Radiotherapy was administered at a median dose of 61 Gy (range, 30-71 Gy). Concurrent chemotherapy was administered to all patients: intra-arterial infusion in 21, systemic infusion in 24, or both in 3. Results: Thirty-seven cases (77%) achieved a complete response. The 3-year local control, progression-free survival (PFS), overall survival (OS), and laryngeal preservation rates were 56%, 48%, 56%, and 73%, respectively. Tumor location, nodal involvement, and pre-treatment serum hemoglobin values were identified as predisposing factors for local control, PFS, and OS. Multivariate analysis revealed that the pre-treatment serum hemoglobin levels and tumor location were significant prognostic factors for PFS. Conclusion: Tumor location and pre-treatment hemoglobin levels are important prognostic factors for PFS for non-surgical multimodal organ preservation treatment.