TY - JOUR T1 - Clinical Significance of an Inflammation-based Prognostic System for Gastric Cancer Patients with a Preoperative Normal Serum Level of Carcinoembryonic Antigen JF - Anticancer Research JO - Anticancer Res SP - 7219 LP - 7226 VL - 34 IS - 12 AU - MITSURU ISHIZUKA AU - YUSUKE OYAMA AU - AKIHITO ABE AU - KAZUMA TAGO AU - GENKI TANAKA AU - KEIICHI KUBOTA Y1 - 2014/12/01 UR - http://ar.iiarjournals.org/content/34/12/7219.abstract N2 - Aim: To investigate the significance of the Glasgow Prognostic Score (GPS) for predicting the postoperative survival of gastric cancer (GC) patients with a normal preoperative serum level of carcinoembryonic antigen (CEA). Because CEA is a useful marker for prognostication of several types of cancer, some patients with GC have a normal CEA level. On the other hand, the GPS has been established as a valuable inflammation-based prognostic system for cancer patients. Patients and Methods: Among 650 patients who had undergone elective surgery for GC, 425 with a normal preoperative serum CEA level (≤5.0 ng/ml) were enrolled. Uni- and multivariate analyses were performed to evaluate the relationship of the GPS to overall survival. The Kaplan-Meier analysis and log rank test were used to compare the survival curves among patients with GPS 0, 1 and 2. Results: Multivariate analysis using clinical characteristics selected from univariate analyses revealed that the GPS (0, 1/2) was associated with overall survival (hazard ratio=2.048; 95% C.I. (confidence interval)=1.002-4.185; p=0.049) along with age (≤70/>70) (years), sex, tumor type (3, 4, 5/0, 1, 2), lymph node metastasis (presence/absence) and platelet count (≤35/>35) (×104/mm3). The Kaplan-Meier analysis and log rank test demonstrated that there were significant differences in overall survival among patients with GPS 0, 1 and 2 (p<0.001). Conclusion: Even if GC patients have a normal serum level of CEA, the GPS is able to predict their postoperative survival and classify such patients into three independent groups before surgery. ER -