%0 Journal Article %A CHRISTOS DAMASKOS %A THEODORE KARATZAS %A IOANNIS D. KOSTAKIS %A LAMPROS NIKOLIDAKIS %A ALKIVIADIS KOSTAKIS %A GREGORY KOURAKLIS %T Nuclear Receptors in Pancreatic Tumor Cells %D 2014 %J Anticancer Research %P 6897-6911 %V 34 %N 12 %X Aim: This review focuses on nuclear receptors expressed in pancreatic cancer. Materials and Methods: An extensive search of articles published up to March 2013 was conducted using the MEDLINE database. The key words used were “pancreatic cancer”, “molecular receptors” and “growth factors”. A total of 112 articles referred to pancreatic cancer, molecular receptors and/or growth factors were included. Results: Receptors of growth factors, such as the epithelial growth factor receptor, insulin-like growth factor-1 receptor, vascular endothelial growth factor receptor and others, such as integrin α5β1, somatostatin receptors, the death receptor 5, claudin, notch receptors, mesothelin receptors, follicle-stimulating hormone receptors, the MUC1 receptor, the adrenomedullin receptor, the farnesoid X receptor, the transferrin receptor, sigma-2 receptors, the chemokine receptor CXCR4, the urokinase plasminogen activator receptor, the ephrine A2 receptor, the GRIA3 receptor, the RON receptor and the angiotensin II receptor AT-1 are expressed in pancreatic tumor cells. These molecules are implicated in tumor growth, apoptosis, angiogenesis, metastasis etc. Conclusion: After identifying the molecular receptors associated with the pancreatic cancer, many more target molecules playing important roles in tumor pathophysiology and senescence-associated signal transduction in cancer cells will be identified. This may have a significant influence on diagnosis, therapy and prognosis of pancreatic cancer. %U https://ar.iiarjournals.org/content/anticanres/34/12/6897.full.pdf