@article {RADES7309, author = {DIRK RADES and STEFAN HUTTENLOCHER and MARKUS DAHLKE and DAGMAR HORNUNG and OLIVER BLANCK and PHAM VAN THAI and NGO THUY TRANG and MAI TRONG KHOA and STEVEN E. SCHILD}, title = {Comparison of Two Dose Levels of Stereotactic Radiosurgery for 1-3 Brain Metastases from Non-small Cell Lung Cancer}, volume = {34}, number = {12}, pages = {7309--7313}, year = {2014}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: Two dose groups of patients treated with stereotactic radiosurgery (SRS) alone for 1-3 brain metastases from non-small cell lung cancer (NSCLC) were compared for outcomes. Patients and Methods: Based on the SRS dose administered to the margins of the brain lesions, 46 patients were assigned to groups treated with 15-18 Gy (n=13) or with 20 Gy (n=33). Seven additional factors were investigated: age (<=58 vs. >=59 years), gender, Karnofsky performance score (KPS 70-80 vs. 90-100), number of brain metastases (1 vs. 2-3), histology (adenocarcinoma vs. other) extracerebral metastases and interval from NSCLC diagnosis to SRS (<=6 vs. \>6 months). Results: Local control rates for 15-18-Gy and 20-Gy groups were 75\% and 92\% at one year (p=0.043). SRS dose was significant on multivariate analysis (p=0.030). SRS dose was not associated with freedom from new brain metastases (p=0.24) or survival (p=0.37). Conclusion: SRS with 20 Gy resulted in better control of the irradiated metastases than 15-18 Gy did.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/34/12/7309}, eprint = {https://ar.iiarjournals.org/content/34/12/7309.full.pdf}, journal = {Anticancer Research} }