RT Journal Article
SR Electronic
T1 Expression of Adhesion Molecules and the Proliferative Activity of Carcinosarcoma of the Ovary
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 7351
OP 7356
VO 34
IS 12
A1 HIROSHI HIRANO
A1 TOMOHIKO KIZAKI
A1 TAKASHI ITO
A1 AKIRA OKIMURA
A1 KOJI YAMANEGI
A1 KEIJI NAKASHO
YR 2014
UL http://ar.iiarjournals.org/content/34/12/7351.abstract
AB Background: To clarify the mechanism underlying the formation of a sarcomatous component of ovarian carcinosarcoma, we investigated the expression of adhesion molecules and the proliferative activity of carcinosarcomas. Materials and Methods: We immunohistochemically examined the expression of E-cadherin and β-catenin, and the Ki-67 labeling index (Ki-67 LI) in six carcinosarcomas containing endometrioid carcinoma as a carcinomatous component. Results: The sarcomatous components of the carcinosarcomas did not express E-cadherin or β-catenin. All carcinomatous components expressed these molecules but the expression was reduced compared to that in endometrioid ovarian carcinomas. In five of the six carcinosarcomas, the Ki-67 LI of the sarcomatous component was less than that of the carcinomatous component. Conclusion: The present results suggest that a carcinomatous component transforms more easily than an ordinary endometrioid carcinoma from the viewpoint of the cell adhesion, and cells in a carcinomatous component continuously transform into sarcomatous cells during the growth of carcinosarcoma.