@article {HIRANO7351, author = {HIROSHI HIRANO and TOMOHIKO KIZAKI and TAKASHI ITO and AKIRA OKIMURA and KOJI YAMANEGI and KEIJI NAKASHO}, title = {Expression of Adhesion Molecules and the Proliferative Activity of Carcinosarcoma of the Ovary}, volume = {34}, number = {12}, pages = {7351--7356}, year = {2014}, publisher = {International Institute of Anticancer Research}, abstract = {Background: To clarify the mechanism underlying the formation of a sarcomatous component of ovarian carcinosarcoma, we investigated the expression of adhesion molecules and the proliferative activity of carcinosarcomas. Materials and Methods: We immunohistochemically examined the expression of E-cadherin and β-catenin, and the Ki-67 labeling index (Ki-67 LI) in six carcinosarcomas containing endometrioid carcinoma as a carcinomatous component. Results: The sarcomatous components of the carcinosarcomas did not express E-cadherin or β-catenin. All carcinomatous components expressed these molecules but the expression was reduced compared to that in endometrioid ovarian carcinomas. In five of the six carcinosarcomas, the Ki-67 LI of the sarcomatous component was less than that of the carcinomatous component. Conclusion: The present results suggest that a carcinomatous component transforms more easily than an ordinary endometrioid carcinoma from the viewpoint of the cell adhesion, and cells in a carcinomatous component continuously transform into sarcomatous cells during the growth of carcinosarcoma.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/34/12/7351}, eprint = {https://ar.iiarjournals.org/content/34/12/7351.full.pdf}, journal = {Anticancer Research} }