TY - JOUR T1 - Relevance of Pelvic and Para-aortic Node Metastases in Early-stage Ovarian Cancer JF - Anticancer Research JO - Anticancer Res SP - 6735 LP - 6738 VL - 34 IS - 11 AU - CORNELIA BACHMANN AU - BERNHARD KRÄMER AU - SARA Y. BRUCKER AU - ANETTE STÄBLER AU - FALKO FEND AU - DIETHELM WALLWIENER AU - EVA MARIA GRISCHKE AU - RALF ROTHMUND Y1 - 2014/11/01 UR - http://ar.iiarjournals.org/content/34/11/6735.abstract N2 - Aim: To delineate the relevance of pelvic and para-aortic node involvement in early-stage ovarian cancer. Patients and Methods: Data on 75 consecutive patients with primary stage T1 and 2 ovarian cancer treated at the Department of Gynecology, University Tuebingen, Germany were retrospectively analyzed. All patients underwent stage-related surgery with pelvic and para-aortic lymphadenectomy and adjuvant platinum-based chemotherapy (except pT1aG1). Median follow up was 53.5 months. Clinico-pathological parameters and the distribution pattern of node metastases were evaluated. Statistical analyses were performed using PASW. Results: Lymph node metastases were detectable in T1 and T2 in 6 (8%) of 75 patients. Three patients (4%) had lymph node metastases in the pelvic nodes only, 2 patients (2.7%) in the para-aortic nodes only; 1 patient (1.3%) both in the pelvic and para-aortic nodes. On multivariate analysis, histological grade 1/ 2 and 3 tumors, serous and endometrioid histology were independent predictors for node metastases, respectively. The risk of relapse was significantly higher with detection of node metastases (p=0.004). Conclusion: A systematic lymphadenectomy in early-stage ovarian cancer leads to an upstaging in a few patients after detection of node metastases even in pelvic or para-aortic nodes, especially in patients with grade 3 tumours and serous cancers. Pelvic and para-aortic lymphadenectomy may detect node involvement in early-stage ovarian cancer and might be helpful in correct staging. ER -